cdk2 cyclin a2  (Carna Inc)

Journal: RSC Advances

Article Title: Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives †

doi: 10.1039/d4ra03126a

Figure Lengend Snippet: The effect of compound 14 on HGC-27 cell cycle. (A) Flow cytometry and (B) bar graph analysis of cell cycle distribution in HGC-27 after treatment with compound 14 (0, 0.10, 0.45, 0.90 μM) for 48 h. (C) Western blot images and (D) bar graph analysis of p53, CDK2 and Cyclin A protein expressions in HGC-27 after treatment with compound 14 (0, 0.10, 0.45, 0.90 μM) for 24 h. * p < 0.05; ** p < 0.01; **** p < 0.0001.

Article Snippet: Antibodies against p53, CDK2, Cyclin A and Calnexin were purchased from Proteintech (Wuhan, China).

Techniques: Flow Cytometry, Western Blot

Journal: BMC Chemistry

Article Title: Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

doi: 10.1186/s13065-024-01139-w

Figure Lengend Snippet: ∆G and binding affinity (Kcal/mol) for CDK2 docking interaction with compound 7e in comparison its standard stu299

Article Snippet: The CDK2/cyclin A2 protein kinase assay was performed according to the bioscience protocol (code #79599) ( www.bpsbioscience.com ).

Techniques: Binding Assay, Comparison

Journal: BMC Chemistry

Article Title: Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

doi: 10.1186/s13065-024-01139-w

Figure Lengend Snippet: 3D and 2D docking interaction of compound 7e with CDK2 in compered to the slandered STU299

Article Snippet: The CDK2/cyclin A2 protein kinase assay was performed according to the bioscience protocol (code #79599) ( www.bpsbioscience.com ).

Techniques:

Journal: BMC Chemistry

Article Title: Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

doi: 10.1186/s13065-024-01139-w

Figure Lengend Snippet: CDK2 inhibitory activity of compound 7e

Article Snippet: The CDK2/cyclin A2 protein kinase assay was performed according to the bioscience protocol (code #79599) ( www.bpsbioscience.com ).

Techniques: Activity Assay, Inhibition

Journal: BMC Chemistry

Article Title: Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

doi: 10.1186/s13065-024-01139-w

Figure Lengend Snippet: a- CDK2 inhibitory activity of compound 7e. b- DHFR inhibitory activity of compound 8d .

Article Snippet: The CDK2/cyclin A2 protein kinase assay was performed according to the bioscience protocol (code #79599) ( www.bpsbioscience.com ).

Techniques: Activity Assay